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The Australian Science and Mathematics School was designed explicitly to support a renaissance in the teaching of science and to improve the engagement of students in the disciplines of science through highly engaging authentic learning opportunities. The school has adopted an action research approach as a means of re-thinking the elements of schooling and of its science programs. Its working premise is that quality science education is embedded in quality schooling. Science is learned through an innovative interdisciplinary curriculum with a pedagogy aligned to the inquiry methodologies associated with deep engagement in scientific endeavour. The architecturally designed school has transformed the traditional, stereotypical roles of teachers and learners. A strategic partnership with Flinders University has been pivotal in promoting leading edge, emergent sciences in the curriculum and providing professional learning opportunities for staff. The school is now in its fourth year of operation and this paper reflects on key elements that define the school and its science education programs as innovative and transformative.